NK Cell Therapy (Help The Body Fight Cancer)

· Those in Tokyo who seek a breakthrough cancer treatment or immune system support.
· Those with relapsed or refractory cancers.
· Those with chronic viral infections (e.g., HIV, hepatitis B, hepatitis C).
· Those with autoimmune diseases (e.g., rheumatoid arthritis) looking for immune regulation.
· Those who want to reduce the risk of graft-versus-host disease (GVHD).

NK Cell Therapy is a new and promising type of immunotherapy called natural killer (NK) cell treatment that uses the body's immune system to treat cancer and other illnesses. An important part of the innate immune system, NK cells are a type of white blood cell that can recognize and eliminate malignant or infectious cells without the requirement for sensitization or previous exposure. The ability of NK cells to eliminate a wide variety of aberrant cells makes them a flexible tool in the battle against cancer, in contrast to T cells, which depend on identifying certain antigens on target cells.

NK Cell Therapy works by enhancing the natural abilities of NK cells as they are naturally present throughout the body to detect and destroy virus-infected or malignant cells.

First, NK cells are collected from the patient or a donor and are activated in a lab to increase their effectiveness. Once activated, the NK cells are infused back into the body. They then seek out and identify specific chemical signals on the surface of stressed or abnormal cells, such as cancerous cells. After attaching to their targets, NK cells release cytotoxic substances like granzymes and perforin, which trigger the target cells to undergo apoptosis (programmed cell death), effectively eliminating the harmful cells.This process enhances the body's ability to fight cancer or infections with fewer side effects than traditional treatments.

NK Cells Therapy are effective in targeting and eliminating abnormal cells, but they don’t stay in the body for long, as their activity is temporary and usually requires follow-up treatments to maintain their effectiveness.

1. NK cells from either the patient’s blood (autologous) or a donor’s blood (allogeneic) will be collected.
2. The collected NK cells in a lab will be activated and enhanced to strengthen their effectiveness in targeting and eliminating abnormal cells.
3. The NK cells will be tested for safety, effectiveness, and purity to ensure they are ready for use in the treatment.
4. The activated NK cells will be infused back into the patient’s bloodstream through an intravenous (IV) drip.
5. The patient will be monitored for any side effects and evaluated on the effectiveness of the treatment through follow-up tests.

<Advantages>
· Kills cancer/infected cells quickly
· Ability to receive from donors with no exact match
· Low risk of Graft-versus-host disease (GVHD) as it is safer than T-cell therapy
· Attacks many types of abnormal cells
· NK cells respond quickly to infected or cancerous cells without prior activation

<Limitations>
· Follow-up treatments required to maintain effectiveness
· NK cells may not be effective against all types of cancer

· Health check is required prior to the treatment
· Certain medications shall be avoided as instructed by the doctor
· Mild chemotherapy may be optional prior to the treatment

· Regular check-ups are required after the treatment
· Monitor side effects such as fever and fatigue for a few hours to a day after the treatment
· Avoid contact with people who are unwell
· Antibiotics or immune boosters may be prescribed by the doctor
· Report any unusual symptoms to the doctor immediately

Q1: What is NK Cell Therapy?
A1: NK Cell Therapy is a treatment using Natural Killer (NK) cells to help the body fight cancer or infections.

Q2: Is NK Cell Therapy safe?
A2: Yes, it is generally safe with mild side effects, while the risk of severe reactions is low.

Q3: What are the common side effects?
A3: Fatigue, fever, chills, mild allergic reactions, or low blood counts for a few hours to a day after the treatment.

Q4: Who can receive NK Cell Therapy?
A4: Mostly cancer patients, especially patients with blood cancers. Also, it depends on the patient's overall health status as well as the doctor’s opinion.

Q5: How is NK Cell Therapy performed?
A5: NK Cell Therapy is usually performed by transferring activated NK cells to the body via IV drip.

Q6: How long does the treatment take?
A6: The treatment may take about 1 to 2 weeks for the collection, preparation, and infusion process to be completed.

Q7: Will I need to stay in the hospital?
A7: Hospitalization may be required, depending on your condition.

Q8: What’s the difference between NK Cell Therapy and CAR-T Therapy?
A8: NK Cell Therapy is safer, quicker-acting with minimal downtime; whereas CAR-T Therapy is more complex and may have stronger side effects.

Q9: Is this treatment widely available?
A9: NK Cell Therapy is currently available only at certain specialized clinics or treatment centres.

Q10: Will my cancer be cured?
A10: The results of NK Cell Therapy may vary depending on your condition. Please consult the doctor at our affiliated clinic for more details and the doctor shall advise on a treatment plan according to the suitability.

[Clinic Name] Forest of Regeneration Clinic Roppongi (Saisei No Mori Clinic)
[Location] Tokyo, Japan
[Nearest Station/ Nearest Tourist Destination] Clinic is located about 5 mins away from The National Art Center and 9 mins Roppngi Tunnel Wallart
[Clinic Opening Time] Monday - Friday (10:00AM - 3:00PM) ; Saturday (10:00AM - 2:00PM) ; Clinic Closed on Sunday, Public Holidays and every 1st, 3rd and 5th Fridays